Symbol
Name
ID

Nckap1l
NCK associated protein 1 like
MGI:1926063

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level	Increased circulating IgG level	Increased B cell count	Increased proportion of memory T cells	Lymphadenopathy	Hepatosplenomegaly	Recurrent otitis media	Recurrent infections	Herpes simplex encephalitis	Molluscum contagiosum
Disease(s) Associated with NCKAP1L
immunodeficiency 72

Mouse Phenotypes

heart inflammation

impaired neutrophil chemotaxis

decreased T cell proliferation

impaired macrophage phagocytosis

impaired neutrophil phagocytosis

abnormal thymus lobule morphology

thymus hypoplasia

spleen hyperplasia

abnormal lymphopoiesis

abnormal CD4-positive T cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

increased neutrophil cell number

decreased mature B cell number

decreased B cell number

decreased NK cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

decreased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased alpha-beta T cell number

increased alpha-beta T cell number

decreased mature gamma-delta T cell number

abnormal regulatory T cell number

decreased lymphocyte cell number

increased leukocyte cell number

increased circulating interleukin-17 level

increased circulating interleukin-6 level

abnormal immune system organ morphology

lymph node hypoplasia

increased interleukin-17 secretion

increased interleukin-6 secretion

increased tumor necrosis factor secretion

liver inflammation

lung inflammation

Availability

Mouse Genotype

Nckap1l^m1Btlr/Nckap1l^m1Btlr

Nckap1l^m1Iri/Nckap1l^m1Iri

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23